Natalizumab-sztn (By injection)

Natalizumab-sztn (na-ta-LYE-zoo-mab - sztn)

Treats Crohn disease and multiple sclerosis (MS).

Brand Name(s):

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. You should not receive it if you had an allergic reaction to natalizumab-sztn, or if you have had progressive multifocal leukoencephalopathy (PML).

How to Use This Medicine:

Injectable

  • Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. This medicine must be injected slowly, so the needle will have to remain in place for about an hour.
  • A nurse or other health provider will give you this medicine.
  • This medicine should come with a Medication Guide. Ask your pharmacist for a copy if you do not have one.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Some medicines can affect how natalizumab-sztn works. Tell your doctor if you are using medicine that weakens your immune system, including azathioprine, cyclophosphamide, cyclosporine, mercaptopurine, methotrexate, mitoxantrone, mycophenolate mofetil, or steroid medicine.

Warnings While Using This Medicine:

  • Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, fever, or any kind of infection (including herpes infection). Tell your doctor if you have a weak immune system (that may be caused by HIV/AIDS, cancer, or an organ transplant).
  • This medicine may cause the following problems:
    • Infections of the brain or nervous system, including PML, encephalitis, retinal necrosis, or meningitis
    • Liver problems
  • Make sure any doctor or dentist who treats you knows that you are using this medicine.
  • You may need to have an MRI scan before you start receiving this medicine.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate, difficult or painful urination, bloody or cloudy urine
  • Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes
  • Fever, chills, runny or stuffy nose, cough, sore throat, body aches
  • Unusual bleeding, bruising, tiredness, or weakness
  • Vaginal itching, discharge, or bleeding
  • Warmth or redness in your face, neck, arms, or upper chest, dizziness
  • Weakness on one side of your body, clumsiness, trouble seeing or vision changes, confusion, memory problems, unusual behavior

If you notice these less serious side effects, talk with your doctor:

  • Arm, leg, joint, or muscle pain
  • Diarrhea, stomach upset
  • Headache
  • Pain, itching, burning, swelling, bleeding, or a lump under your skin where the needle is placed

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088


Last Updated: 9/6/2024

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.

All rights reserved

A.D.A.M. content is best viewed in IE9 or above, Firefox and chrome browser.