Alglucosidase Alfa (al-gloo-KOE-si-dase AL-fa)

Treats Pompe disease.

Brand Name(s):

Lumizyme

When This Medicine Should Not Be Used:

How to Use This Medicine:

Injectable

• Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. It must be given slowly, so the IV will have to remain in place for 4 hours.
• A nurse or other health provider will give you this medicine.
• Your doctor will give you other medicines (including allergy, fever, or steroid medicine) before you receive this medicine to help prevent unwanted effects.
• Missed dose: Call your doctor or pharmacist for instructions.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heart disease, or lung disease.
• This medicine may cause the following problems:
  • Infusion-related reactions, which can be life-threatening and require medical attention
  • Immune-mediated reactions, including protein in the urine, kidney problems, and skin reactions
• Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Bloody or cloudy urine, swelling of the face, feet, or lower legs
• Blurred vision, headache, pounding in the ears, slow or fast heartbeat
• Chest pain, trouble breathing, cold sweats, blue lips, fingernails, or skin
• Fever, chills, cough, sore throat, body aches
• Lightheadedness, dizziness, fainting
• Muscle twitching, tremors
• Pain, itching, burning, swelling, or a lump under your skin where the needle is placed
• Skin rash

If you notice these less serious side effects, talk with your doctor:

• Constipation, diarrhea, nausea, vomiting, stomach pain
• Muscle pain
• Increased sweating
• Warmth or redness in your face, neck, arms, or upper chest

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088