Apolipoprotein B100

ApoB100; Apoprotein B100; Hypercholesterolemia - apolipoprotein B100

Definition

Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low density lipoprotein (LDL).

Variants in the gene that directs the body's production of apoB100 can cause a condition called familial hypercholesterolemia. This is a form of high blood cholesterol that is passed down in families (inherited).

This article discusses the test used to measure the level of apoB100 in the blood.

How the Test is Performed

A blood sample is needed.

How to Prepare for the Test

Your health care provider may tell you not to eat or drink anything for 4 to 6 hours before the test.

How the Test will Feel

When the needle is inserted to draw blood, you may feel moderate pain, or only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the Test is Performed

Most often, this test is done to help determine the cause or specific type of high blood cholesterol. It is not clear whether the information helps improve treatment. Because of this, most health insurance companies do not pay for the test. If you do not have a diagnosis of high cholesterol or heart disease, this test may not be recommended for you.

Normal Results

The normal range is about 50 to 150 mg/dL.

Normal value ranges may vary slightly among different laboratories. Some laboratories use different measurements or may test different specimens. Talk to your provider about the meaning of your specific test results.

What Abnormal Results Mean

An abnormal result may mean you have high lipid (fat) levels in your blood. A medical term for this is hyperlipidemia.

Other disorders that may be associated with high apoB100 levels include atherosclerotic vascular disease such as angina pectoris (chest pain that occurs with activity or stress) and heart attack.

Risks

Risks linked with having blood drawn are slight, but may include:

  • Excessive bleeding
  • Fainting or feeling lightheaded
  • Hematoma (blood buildup under the skin)
  • Infection (a slight risk any time the skin is broken)
  • Multiple punctures to locate veins

Considerations

Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown.

References

Bredefeld CL, Lau R, Hussain MM. Lipids and dyslipoproteinemia. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 24th ed. St Louis, MO: Elsevier; 2022:chap 18.

Genest J, Mora S, Libby P. Lipoprotein disorders and cardiovascular disease. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 27.

Libby P. The vascular biology of atherosclerosis. In: Libby P, Bonow RO, Mann DL, Tomaselli GF, Bhatt DL, Solomon SD, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 12th ed. Philadelphia, PA: Elsevier; 2022:chap 24.

Meeusen JW, Ueda M, Nordestgaard BG, Remaley AT. Lipids and lipoproteins. In: Rifai N, Chiu RWK, Young I, Burnham C-A D, Wittwer CT, eds. Tietz Textbook of Laboratory Medicine. 7th ed. St Louis, MO: Elsevier; 2023:chap 36.

Mora S, Martin SS. Measurement of low-density lipoprotein cholesterol, non–high-density lipoprotein cholesterol, apolipoprotein B, and low-density lipoprotein particle concentration. In: Ballantyne CM, ed. Clinical Lipidology: A Companion to Braunwald's Heart Disease. 3rd ed. Philadelphia, PA: Elsevier; 2024:chap 3.

Robinson JG. Disorders of lipid metabolism. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 190.

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Review Date: 5/8/2024

Reviewed By: Thomas S. Metkus, MD, Assistant Professor of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.


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