Definition

Erythroplasia of Queyrat is an early form of skin cancer found on the penis. The cancer is called squamous cell carcinoma in situ. Squamous cell cancer in situ can occur on any part of the body. This term erythroplasia of Queyrat is used only when the cancer occurs on the penis.

Causes

The condition is most often seen in men who have not been circumcised. It is linked to the human papillomavirus (HPV).

Symptoms

The main symptoms are a rash and irritation on the tip or shaft of the penis that persists. The area is most often red and does not respond to topical creams.

Exams and Tests

Your health care provider will examine the penis to diagnose the condition and will perform a biopsy to make the diagnosis.

Treatment

Treatment may include:

• Skin creams such as imiquimod or 5-fluorouracil. These creams are used for several weeks to months.
• Anti-inflammatory (steroid) creams.

If skin creams do not work, your provider may recommend other treatments such as:

• Mohs micrographic surgery or other surgical procedures to remove the area
• Laser surgery
• Freezing the cancer cells (cryotherapy)
• Scraping away cancer cells and using electricity to kill any that remain (curettage and electrodesiccation)

Outlook (Prognosis)

The prognosis for cure is excellent in most cases.

When to Contact a Medical Professional

You should contact your provider if you have rashes or sores on the genitalia that do not go away.

References

Dinuos JGH. Premalignant and malignant nonmelanoma skin tumors. In: Dinulos JGH, ed. Habif's Clinical Dermatology. 7th ed. Philadelphia, PA: Elsevier; 2021:chap 21.

James WD. Epidermal nevi, neoplasms, and cysts. In: James WD, ed. Andrews' Diseases of the Skin: Clinical Dermatology. 14th ed. Philadelphia, PA: Elsevier; 2026:chap 24.