Substance use - inhalants

Many household products have chemicals that are volatile. Volatile means the chemical produces vapors, which can be breathed in (inhaled). Common types of abused inhalants are:

Inhalants are breathed in through the mouth or nose. Slang terms for these methods are:

Other things that are often used to hold inhalant chemicals include empty soda cans, empty perfume bottles, and toilet paper tubes stuffed with rags or toilet paper soaked with the chemical.

When inhaled, the chemicals are absorbed by the lungs. Within seconds, the chemicals go to the brain, causing the person to feel intoxicated, or high. The high usually involves feeling excited and happy, a feeling similar to being drunk from drinking alcohol.

Some inhalants cause the brain to release dopamine. Dopamine is a chemical that is involved with mood and thinking. It is also called the feel-good brain chemical.

Because the high lasts only a few minutes, users try to make the high last longer by inhaling repeatedly for several hours.

Nitrites are different from other inhalants. Nitrites make blood vessels larger and the heart beat faster. This causes the person to feel very warm and excited. Nitrites are often inhaled to improve sexual performance rather than to get high.

Chemicals in inhalants can harm the body in many ways, leading to health problems such as:

Inhalants can also be deadly:

People who inhale nitrites have a high chance of getting HIV/AIDS and hepatitis B and C. This is because nitrites are used to improve sexual performance. People who use nitrites may have unsafe sex.

Inhalants can cause birth defects when used during pregnancy.

People who use inhalants can get addicted to them. This means their mind and body are dependent on the inhalants. They are not able to control their use and they need (crave) them to get through daily life.

Addiction can lead to tolerance. Tolerance means that more and more of the inhalant is needed to get the same high feeling. And if the person tries to stop using the inhalant, reactions may result. These are called withdrawal symptoms and may include:

Physical reactions may include headaches, aches and pains, increased appetite, and not sleeping well.

It is not always easy to tell if someone is using inhalants. Be alert for these signs:

Treatment begins with recognizing the problem. The next step is getting help and support.

Treatment programs use behavior change techniques through counseling (talk therapy). The goal is to help the person to understand their behavior and why they use inhalants. Involving family and friends during counseling can help support the person to keep them from going back to using (relapsing).

At this time, there is no medicine that can help reduce the use of inhalants by blocking their effects. But, scientists are researching such medicines.

As the person recovers, encourage the following to help prevent relapse:

Helpful resources include:

For adults, your workplace employee assistance program (EAP) is also a good resource.

Contact your health care provider if you or someone you know is addicted to inhalants and needs help stopping. Also contact your provider if you are having withdrawal symptoms that concern you.

Breuner CC. Substance use disorder. In: Kliegman RM, St. Geme JW, Blum NJ, et al, eds. Nelson Textbook of Pediatrics. 22nd ed. Philadelphia, PA: Elsevier; 2025:chap 157.

Nguyen J, O'Brien C, Schapp S. Adolescent inhalant use prevention, assessment, and treatment: a literature synthesis. Int J Drug Policy. 2016;31:15-24. PMID: 26969125 pubmed.ncbi.nlm.nih.gov/26969125/.

United States Drug Enforcement Administration (DEA). Inhalants. www.dea.gov/factsheets/inhalants. Updated October 2022. Accessed June 13, 2024.

Weiss RD, Liebschutz JM. Drug use disorders. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 365.



Review Date: 5/4/2024
Reviewed By: Fred K. Berger, MD, addiction and forensic psychiatrist, Scripps Memorial Hospital, La Jolla, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
© 1997- adam.comAll rights reserved.
A.D.A.M. content is best viewed in IE9 or above, Firefox and Google Chrome browser.