Definition

Strongyloidiasis is an infection with the roundworm Strongyloides stercoralis (S stercoralis).

Alternative Names

Intestinal parasite - strongyloidiasis; Roundworm - strongyloidiasis

Causes

S stercoralis is a roundworm that is fairly common in warm, moist areas. In rare cases, it can be found as far north as Canada.

People catch the infection when their skin comes in contact with soil that is contaminated with the worms.

The tiny worm is barely visible to the naked eye. Young roundworms can move through a person's skin and eventually into the bloodstream to the lungs and airways.

They then move up to the throat, where they are swallowed into the stomach. From the stomach, the worms move to the small intestine, where they attach to the intestinal wall. Later, they produce eggs, which hatch into tiny larvae (immature worms) and pass out of the body.

Unlike other worms, these larvae can re-enter the body through the skin around the anus, which allows an infection to grow. Areas where the worms go through the skin can become red and painful.

This infection is uncommon in the United States, but it does occur in the southeastern US. Most cases in North America are brought by travelers who have visited or lived in South America or Africa.

Some people are at risk for a severe type called strongyloidiasis hyperinfection syndrome. In this form of the condition, there are more worms and they multiply more quickly than normal. It can occur in people who have a weakened immune system. This includes people who have had an organ or blood-product transplant, people with HIV/AIDS, and those who take steroid medicine or immune-suppressing drugs.

Symptoms

Most of the time, there are no symptoms. If there are symptoms, they may include:

• Abdominal pain (upper abdomen)
• Cough
• Diarrhea
• Rash
• Red hive-like areas near the anus
• Vomiting
• Weight loss
• Fever

Exams and Tests

The following tests may be done:

• Blood tests such as complete blood count with differential, eosinophil count (a type of white blood cell), antigen test for S stercoralis
• Duodenal aspiration (removing a small amount of tissue from the first part of the small intestine) to check for S stercoralis (uncommon)
• Sputum culture to check for S stercoralis
• Stool sample exam to check for S stercoralis

Treatment

The goal of treatment is to eliminate the worms with anti-worm medicines, such as ivermectin or albendazole.

Sometimes, people with no symptoms are treated. This includes people who take drugs that suppress the immune system, such as those who are going to have, or have had, a transplant.

Outlook (Prognosis)

With proper treatment, the worms can be killed and full recovery is expected. Sometimes, treatment needs to be repeated.

Infections that are severe (hyperinfection syndrome) or that have spread to many areas of the body (disseminated infection) often have a poor outcome, especially in people with a weakened immune system.

Possible Complications

Possible complications include:

• Disseminated strongyloidiasis, particularly in people with HIV or an otherwise weakened immune system
• Strongyloidiasis hyperinfection syndrome, also more common in people with a weakened immune system
• Eosinophilic pneumonia
• Malnutrition due to problems absorbing nutrients from the gastrointestinal tract

When to Contact a Medical Professional

Contact your health care provider for an appointment if you have symptoms of strongyloidiasis.

Prevention

Good personal hygiene can reduce the risk of strongyloidiasis. Public health services and sanitary facilities provide good infection control.

References

Centers for Disease Control and Prevention website. Strongyloides. About strongyloides. www.cdc.gov/strongyloides/about/. Updated June 13, 2024. Accessed June 18, 2024.

Mejia R, Weatherhead J, Hotez PJ. Intestinal nematodes (roundworms). In: Bennett JE, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 9th ed. Philadelphia, PA: Elsevier; 2020:chap 286.