Glomerulonephritis

Glomerulonephritis - chronic; Chronic nephritis; Glomerular disease; Necrotizing glomerulonephritis; Glomerulonephritis - crescentic; Crescentic glomerulonephritis; Rapidly progressive glomerulonephritis

Definition

Glomerulonephritis is a type of kidney disease in which the part of your kidneys that helps filter waste and fluids from the blood is damaged.

Causes

The filtering unit of the kidney is called the glomerulus. Each kidney has many thousands of glomeruli. The glomeruli help the body get rid of harmful substances.

Glomerulonephritis may be caused by problems with the body's immune system. Often, the exact cause of this condition is unknown.

Damage to the glomeruli causes blood and protein to be lost in the urine.

The condition may develop quickly, and kidney function is lost within weeks or months. This is called rapidly progressive glomerulonephritis.

Some people with chronic glomerulonephritis have no history of kidney disease.

The following may increase your risk for this condition:

  • Blood or lymphatic system disorders
  • Exposure to hydrocarbon solvents
  • History of cancer
  • Infections such as strep infections, viruses, heart infections, or abscesses

Many conditions cause or increase the risk for glomerulonephritis, including:

Symptoms

Common symptoms of glomerulonephritis are:

  • Blood in the urine (dark, rust-colored, or brown urine)
  • Foamy urine (due to excess protein in the urine)
  • Swelling (edema) of the face, eyes, ankles, feet, legs, or abdomen

Symptoms may also include the following:

The symptoms of chronic kidney disease may develop over time.

Chronic kidney failure symptoms may gradually develop.

Exams and Tests

Because symptoms may develop slowly, the disorder may be discovered when you have an abnormal urinalysis during a routine physical or examination for another condition.

Signs of glomerulonephritis can include:

A kidney biopsy confirms the diagnosis.

Later, signs of chronic kidney disease may be seen, including:

  • Nerve inflammation (polyneuropathy)
  • Signs of fluid overload, including abnormal heart and lung sounds
  • Swelling (edema)

Imaging tests that may be done include:

Urinalysis and other urine tests include:

This disease may also cause abnormal results on the following blood tests:

Treatment

Treatment depends on the cause of the disorder, and the type and severity of symptoms. Controlling high blood pressure is usually an important part of treatment.

Medicines that may be prescribed include:

  • Blood pressure drugs, most often angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs)
  • Corticosteroids
  • Drugs that suppress the immune system

A procedure called plasmapheresis may sometimes be used for glomerulonephritis caused by immune system problems. The fluid part of the blood that contains antibodies is removed and replaced with intravenous fluids or donated plasma (that does not contain antibodies). Removing antibodies may reduce inflammation in the kidney tissues.

You may need to limit your intake of sodium, fluids, protein, and other substances.

People with this condition should be closely watched for signs of kidney failure. Dialysis or a kidney transplant may eventually be needed.

Support Groups

More information and support for people with glomerulonephritis and their families can be found at kidney disease support group. 

Outlook (Prognosis)

Glomerulonephritis may be temporary and reversible, or it may get worse. Progressive glomerulonephritis may lead to:

If you have nephrotic syndrome and it can be controlled, you may also be able to control other symptoms. If it cannot be controlled, you may develop end-stage kidney disease.

When to Contact a Medical Professional

Contact your health care provider if:

  • You have a condition that increases your risk for glomerulonephritis
  • You develop symptoms of glomerulonephritis

Prevention

Most cases of glomerulonephritis can't be prevented. Some cases may be prevented by avoiding or limiting exposure to organic solvents, mercury, and nonsteroidal anti-inflammatory drugs (NSAIDs).

References

Radhakrishnan J, Stokes MB. Glomerular disorders and nephrotic syndromes. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 107.

Radhakrishnan J, Appel GB, D'Agati VD. Secondary glomerular disease. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 32.

Reich HN, Cattran DC. Treatment of glomerulonephritis. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 33.

Saha MK, Pendergraft WF, Jennette JC, Falk RJ. Primary glomerular disease. In: Yu ASL, Chertow GM, Luyckx VA, Marsden PA, Skorecki K, Taal MW, eds. Brenner and Rector's The Kidney. 11th ed. Philadelphia, PA: Elsevier; 2020:chap 31.

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Review Date: 8/28/2023

Reviewed By: Walead Latif, MD, Nephrologist and Clinical Associate Professor, Rutgers Medical School, Newark, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.


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