Toxic megacolon

Previous imageEnlargeCloseNext image
 

 /   

schedule An Appointment
Toxic dilation of the colon; Megarectum; Inflammatory bowel disease - toxic megacolon; Crohn disease - toxic megacolon; Ulcerative colitis - toxic megacolon

Definition

Toxic megacolon occurs when swelling and inflammation spread into the deeper layers of your colon. As a result, the colon stops working and widens. In severe cases, the colon may rupture.

Causes

The term "toxic" means that this problem is very dangerous. Toxic megacolon may occur in people with an inflamed colon due to:

  • Ulcerative colitis, or Crohn disease that is not well controlled
  • Infections of the colon such as Clostridioides difficile
  • Ischemic bowel disease (ischemic colitis)

Other forms of megacolon include pseudo-obstruction, acute colonic ileus, or congenital colonic dilation. These conditions do not involve an infected or inflamed colon.

Symptoms

The rapid widening of the colon may cause the following symptoms to occur over a short period of time:

Exams and Tests

The health care provider will perform a physical exam. Findings may include:

The exam may reveal signs of septic shock, such as:

  • Increased heart rate
  • Mental status changes
  • Rapid heart rate
  • Low blood pressure

The provider may order any of the following tests:

Treatment

Treatment of the disorder that led to toxic megacolon includes:

  • Steroids and other medicines that suppress the immune system
  • Antibiotics

If you have septic shock, you will be admitted to the intensive care unit (ICU) of the hospital. Treatment may include:

  • Breathing machine (mechanical ventilation)
  • Dialysis for kidney failure
  • Fluids given directly into a vein
  • Medicines to treat low blood pressure, infection, or prior blood clotting
  • Oxygen

If rapid colon widening is not treated, an opening or rupture can form in it. If the condition doesn't improve with medical treatment, surgery will be needed to remove part or all of the colon.

You may receive antibiotics to prevent sepsis (a severe infection).

Outlook (Prognosis)

If the condition does not improve, it can be fatal. Colon surgery is usually needed in such cases.

Possible Complications

Complications may include:

  • Perforation of the colon
  • Sepsis
  • Shock
  • Death

When to Contact a Medical Professional

Go to the emergency room or call the local emergency number (such as 911) if you develop severe abdominal pain, especially if you also have:

  • Bloody diarrhea
  • Fever
  • Frequent diarrhea
  • Rapid heart rate
  • Tenderness when the abdomen is pressed
  • Abdominal distention

Prevention

Treating diseases that cause toxic megacolon, such as ulcerative colitis or Crohn disease, can prevent this condition.

References

Efron JE. Large bowel: Management of toxic megacolon. In: Cameron J, ed. Current Surgical Therapy. 14th ed. Philadelphia, PA: Elsevier; 2023:177-286.

Lichtenstein GR. Inflammatory bowel disease. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 127.

Thomas N, Wu AW. Large intestine. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 81.

Schedule An Appointment

Review Date: 12/31/2023

Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Aria - Jefferson Health Torresdale, Jefferson Digestive Diseases Network, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.


View References

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. No warranty of any kind, either expressed or implied, is made as to the accuracy, reliability, timeliness, or correctness of any translations made by a third-party service of the information provided herein into any other language. © 1997- A.D.A.M., a business unit of Ebix, Inc. Any duplication or distribution of the information contained herein is strictly prohibited.