Thiazide diuretics include:

• Chlorothiazide (Diuril)
• Hydrochlorothiazide (Aquazide, Esidrix, Ezide, Hydrocot, HydroDIURIL, Microzide, Oretic)
• Indapamide (Lozol)
• Methyclothiazide (Aquatensen, Enduron)
• Metolazone (Mykrox, Zaroxolyn)
• Chlorthalidone (Thalitone)
• Bendroflumethiazide (Naturetin)

Thiazide diuretics and potassium-sparing diuretics may sometimes be used together. Diuretic combinations include:

• Hydrochlorothiazide/triamterene (Maxzide, Dyazide)
• Hydrochlorothiazide/ spironolactone (Aldactazide)
• Amiloride/ hydrochlorothiazide (Moduretic)

Depletions from thiazide diuretics are discussed in this article. If you are taking any of these combinations, you may also want to consult the potassium-sparing diuretics depletion article.

Taking thiazide diuretics may deplete sodium, magnesium and potassium.

Sodium

Sodium deficiency is rare because it is widely available in dietary sources. When it does occur, low levels have been associated with:

• Weakness
• Nausea and vomiting
• Headache
• Confusion
• Memory impairment
• Reduced attention
• Muscle cramps
• Strong, rapid or irregular heartbeat
• Lack of energy
• Restlessness

Severe cases can cause seizures, loss of consciousness, and possibly coma. The development of symptoms depends on how fast you lose sodium.

Magnesium

Magnesium deficiency affects calcium and vitamin D levels in the body. This may cause:

• Muscle cramps
• Muscle weakness
• Irregular heartbeat
• Numbness and tingling in feet and toes
• Seizures
• Insomnia
• High blood pressure

Potassium

Symptoms of potassium deficiency include:

• Nausea and vomiting
• Tiredness
• Drowsiness
• Feeling of apprehension
• Weakness
• Muscle pain and weakness (mostly in the legs)
• Muscle cramps
• Strong, rapid or irregular heartbeat

The information presented here covers some of the nutrients that may be affected when you take certain medicines. If you have any of these signs and symptoms, it does not always mean you have low levels of these nutrients.

Factors that affect the level of nutrients are:

• Your medical history
• Diet
• Lifestyle
• How long you have been taking the medicine

Please talk to your health care provider. They can best address your health care needs and see if you are at risk for low levels of any nutrients.

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Gold Standard Drug Database. Drug Monograph: Bendroflumethiazide, 2015. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1205. Accessed July 13, 2016.

Gold Standard Drug Database. Drug Monograph: Chlorthalidone, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-122. Accessed July 13, 2016.

Gold Standard Drug Database. Drug Monograph: Chlorothiazide, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-1249. Accessed July 11, 2016.

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Gold Standard Drug Database. Drug Monograph: Metolazone, 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-396. Accessed July 11, 2016.

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