Migraines can be triggered by many everyday things. Different people respond to different triggers, so it is important to track your migraine patterns to help you identify and avoid things that set off your migraine attacks. Common migraine triggers include:
Migraines need a two-pronged approach: treatment and prevention. Treatment uses medications that provide quick pain relief when attacks occur. These drugs include pain relievers such as nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen (Tylenol, generic), triptans such as sumatriptan (Imitrex, generic), and ergotamine drugs.
Preventive strategies begin with non-drug approaches, including behavioral therapies and lifestyle changes. If headache attacks continue to occur at least once a week, or if your attacks do not respond well to treatment, your doctor may recommend you try preventive medication. Drugs used for migraine prevention include anticonvulsants, beta-blockers, antidepressants, and Botox. The herbal remedy butterbur may be effective.
Newer treatments being evaluated include:
The American Headache Society recommends against these migraine tests and procedures because they are unnecessary, and potentially harmful:
Migraine headaches are the second most common type of primary headache after tension-type headaches. A primary headache is a headache that is not caused by another disease or condition.
Migraine headaches typically have throbbing disabling pain on one side of the head, which sometimes spreads to affect the entire head. In fact, migraine comes from the Greek word hemicrania, meaning "half of the head."
Migraines are classified as occurring either:
Auras are sensory disturbances that occur before a migraine attack. They can cause changes in vision, with or without other neurologic symptoms.
Migraines usually occur as isolated episodic attacks, which can happen once a year or several times in 1 week. In some cases, people eventually experience chronic migraine (previously called transformed migraine).
Chronic migraines typically begin as episodic headaches when people are in their teens or 20s, and then increase in frequency over time. A headache is considered chronic when it occurs on at least 15 days in a month, often on a daily or near-daily basis.
The majority of chronic migraines are caused by overuse of analgesic migraine medications, both prescription pain reliever drugs and over-the-counter medications. Medication overuse headaches are also called rebound headaches. Obesity and caffeine overuse are other factors that may increase the risk of episodic migraine transforming to chronic migraine.
Chronic migraines may resemble tension-type headaches and it is sometimes difficult to differentiate between them. The two types of headaches can coexist. It is not uncommon for people with migraine headaches to also have tension-type headaches.
Less common type of migraines include:
The exact causes of migraine headaches are unknown. There is certainly a strong genetic component to migraines. Several different genes are probably involved, which predispose people to having migraines.
Many brain chemicals (neurotransmitters) and nerve pathway disrupters appear to play a role in causing migraines. They include the neurotransmitter serotonin, magnesium deficiencies, and abnormalities in the channels within cells that transport electrical ions such as calcium.
Migraine may involve a hyper-reactive nervous system. When triggered by various stimuli, this disorder may set off a chain of neurologic and biochemical events, which subsequently affect the brain's blood vessel (vascular) system.
Migraines are three times more common in adult women than adult men. During childhood, boys and girls are equally affected. After puberty, migraines occur more in girls. Migraines most often affect women ages 20 to 45.
In women, fluctuations of female hormones such as estrogen and progesterone appear to increase the risk for migraines and their severity. About one half of women with migraines report headaches associated with their menstrual cycle. For some women, migraines also tend to be worse during the first trimester of pregnancy, but improve during the last trimester.
Migraine headaches typically affect people ages 25 to 55. However, migraine also affects about 5% to 10% of all children. Many children with migraine eventually stop having attacks when they reach adulthood or transition to less severe tension-type headaches. Children with a family history of migraine may be more likely to continue having migraines.
Migraines tend to run in families. Most people with migraine have a family history of the condition.
People with migraine may have a history of depression, anxiety, stroke, epilepsy, irritable bowel syndrome, or high blood pressure. These conditions do not necessarily increase the risk for migraine, but they are associated with it.
Migraines are often triggered by certain events and conditions. Common migraine triggers include:
A migraine attack may involve up to 4 symptom phases: prodrome phase, auras, the attack, and the postdrome phase. These phases may not occur in every person or with every headache.
The prodrome phase is a group of vague symptoms that may precede a migraine attack by several hours, or even a day or two. Prodrome symptoms may include:
Auras are sensory disturbances that occur before the migraine attack in 1 in 5 people. Visually, auras are referred to as being positive or negative:
Other neurologic symptoms may occur at the same time as the aura, although they are less common. They may include:
If left untreated, attacks usually last from 4 to 72 hours. A typical migraine attack produces the following symptoms:
Less common symptoms include tearing and redness in one eye, swelling of the eyelid, and nasal congestion, including runny nose. (Such symptoms are more common in certain other headaches, notably cluster headaches.)
After a migraine attack, there is usually a postdrome phase, in which people may feel exhausted and mentally foggy for a while.
Migraine or severe headache is a risk factor for stroke in both men and women, especially before age 50. Research indicates that migraine may also increase the risk for other types of heart problems.
Migraine with aura appears to carry a higher risk for stroke than migraine without aura, especially for younger women. The increased risk is very low, but it is important that women with migraine avoid other stroke risks such as smoking and possibly birth control pills.
Some studies suggest that people who have migraine with aura are more likely than people without migraine to have cardiovascular risk factors (such as high cholesterol and high blood pressure) that increase the risk for stroke.
Migraines have a significant negative impact on quality of life, family relations, and work productivity. Studies indicate that people with migraines have poorer social interactions and emotional health than people with many other chronic medical illnesses, including asthma, diabetes, and arthritis. Many people who have migraines also suffer from anxiety (particularly panic disorders) and depression.
Anyone, including children, with recurring or persistent headaches should consult a health care provider. There are no blood tests or imaging techniques that can be used to diagnose migraine headaches. A diagnosis will be made on the basis of medical history and physical exam. Tests may be necessary to rule out other diseases or conditions that may be causing the headaches. For chronic headaches, your provider may refer you to a neurologist who specializes in migraine.
A diagnosis of migraine is often made on the basis of repeated attacks (at least 5) that meet the following criteria:
Try to recall what seems to bring on the headache and anything that relieves it. Keeping a headache diary is a useful way to identify triggers that bring on headaches, as well as to track the duration and frequency of headache attacks. Some tips include:
1 = Mild, barely noticeable
2 = Noticeable, but does not interfere with work/activities
3 = Distracts from work/activities
4 = Makes work/activities very difficult
5 = Incapacitating
Tell your provider about any other conditions that might be associated with headache, including:
The provider will examine the head and neck and will often perform a neurologic examination, which includes a series of simple exercises to test strength, reflexes, coordination, and sensation. The provider may ask questions to test short-term memory and related aspects of mental function.
Migraine and tension-type headaches have some similar characteristics, but also some important differences:
Many primary headaches, including migraine, are misdiagnosed as sinus headaches. It is also possible for people to have migraines with sinus symptoms such as congestion and facial pressure.
Sinus headaches occur in the front of the face, with pain or pressure around the eyes, across the cheeks, or over the forehead. They are often accompanied by fever, runny nose or congestion, and fatigue. In sinus headaches, the nasal discharge is thick green or yellow. Nasal discharge in migraines is clear and watery.
A real sinus headache is a sign of an acute sinus infection (sinusitis), which responds to treatment with decongestants and may sometimes require antibiotics. If sinus headaches seem to recur, the person is likely experiencing migraines.
The provider may order a magnetic resonance imaging (MRI) scan to check for abnormalities that may be causing the headaches. For people who have migraine headaches that are stable, imaging tests are often not necessary unless there are new and serious symptoms. Symptoms that may suggest neurologic problems that warrant a MRI include:
For imaging tests, MRIs are preferred over computed tomography (CT) scans because they do not expose people to radiation.
Headaches indicating a serious underlying problem, such as cerebrovascular disorder or malignant hypertension, are uncommon. A headache without other neurologic symptoms is not a common symptom of a brain tumor. People with chronic headaches may, however, miss a more serious condition by believing it to be one of their usual headaches. You should immediately call your provider if your headache or other accompanying symptoms change.
Be sure to call your provider for any of the following symptoms:
Migraine treatment involves both:
There are many medications for treating a migraine attack. The main types of drugs are:
Some types of medications, such as opioids and barbiturates, should be avoided because they are potentially addictive or dangerous.
It is best to treat a migraine attack as soon as symptoms first occur. Experts generally recommend:
Try to guard against medication overuse, which can cause a rebound effect. Nearly all pain relief drugs used for migraine can cause rebound headache. You should not take any headache medicine more than 2 days per week. This is especially true for OTC medications that contain caffeine. If you find that you need to use acute migraine treatment frequently, talk to your health care provider about preventive medications.
Preventive strategies for migraine include both drug treatment and behavioral therapy or lifestyle adjustments.
People should consider using preventive migraine drugs if they have:
The main preventive drug treatments for migraine are:
OnabotulinumtoxinA (Botox) injection is approved for prevention of migraine, but it appears to work best for chronic (not episodic) migraine.
Certain herbal and dietary supplements, such as butterbur (Petasites hybridus) and riboflavin, may be effective for migraine prevention.
A preventive medication strategy needs to be carefully and individually tailored, taking into account a person's medical history and coexisting medical conditions. Migraine drugs can have serious side effects.
Preventive medicine is often started at a low dose, and then gradually increased. It may take 2 to 3 months for a drug to achieve its full effect. Preventive treatment may be needed for 6 to 12 months or longer. Most people take preventive medications on a daily basis, but some people use these drugs intermittently (for example, for preventing menstrual migraine).
Some medications, especially certain oral contraceptives, may increase frequency of migraine in some women. In such cases, changing the type of contraceptive or stopping it results in improved migraine control.
You can also help prevent migraines by identifying and avoiding potential triggers, such as specific foods. Relaxation therapy and stress reduction techniques may also help. (See Lifestyle section in this report.)
Most children with migraines need only mild pain relievers and home remedies (such as ginger tea) to treat their headaches. The American Academy of Neurology's practice guidelines for children and adolescents recommend the following drug treatments:
Non-drug methods, including biofeedback and muscle relaxation techniques, may be helpful. If these methods fail, preventive medications may be used, although evidence is weak on the effectiveness of standard migraine prevention drugs in children.
If medication overuse causes rebound migraines to develop, you will need to stop taking the drug. (If caffeine is the trigger, you may only need to reduce coffee or tea intake.) People often have the option of stopping abruptly or gradually:
Many different medications are used to treat migraines. Some migraines respond to non-prescription pain relievers such as ibuprofen, acetaminophen, naproxen, or aspirin. Among prescription drugs, triptans and ergotamine are the only types of medications approved by the U.S. Food and Drug Administration (FDA) for migraine treatment.
Other types of drugs, including opioids and barbiturates, are sometimes prescribed off-label for migraine treatment but they can have dangerous side effects. Opioids and barbiturates are not approved by the FDA for migraine relief.
Over-the-counter (OTC) painkillers, also called analgesics, are available without a prescription. They are the first step for treating mild-to-moderate migraines. They include:
There are also prescription-only NSAIDs such as diclofenac (Cataflam, generic).
High dosages and long-term use of NSAIDs can increase the risk for heart attack, stroke, kidney problems, and stomach bleeding. Aspirin does not increase the risk for heart problems, but it can cause other NSAID-related side effects. Frequent or daily use of NSAIDs may worsen migraines and lead to the development of medication overuse headache. The American Headache Society advises against using OTC medications for headache more than twice a week.
Triptans were the first drugs specifically developed for migraine treatment. They help maintain serotonin levels in the brain. Serotonin is one of the major brain chemicals involved in migraines.
Triptans are recommended as first-line drugs for adults with moderate-to-severe migraines when NSAIDs are not effective. Triptans have the following benefits:
Sumatriptan (Imitrex, generic) has the longest track record and is the most studied of all triptans. Sumatriptan is effective for most people, but for some people headache recurs within 24 hours after taking the drug.
Sumatriptan is available as a fast-dissolving pill, nasal spray, injection, or skin patch. Injected sumatriptan works the fastest of all the triptans and is the most effective, but it can cause pain at the injection site. The nasal spray form is absorbed more quickly than the oral form and can provide relief within 15 minutes.
The newest form of sumatriptan (Zecurity) is a single-use battery-powered skin patch that is applied to the upper arm or thigh when a migraine attack occurs. Pressing a button activates the patch to deliver the drug during a 4-hour period. The patch is approved to treat both migraine pain and nausea.
Other triptan drugs include almotriptan (Axert), zolmitriptan (Zomig), naratriptan (Amerge, generic), rizatriptan (Maxalt), frovatriptan (Frova), and eletriptan (Relpax). Treximet combines in one pill both sumatriptan and the anti-inflammatory pain reliever naproxen (Aleve, generic). Frovatriptan is recommended for prevention of menstrual migraine; naratriptan and zolmitriptan may also possibly be effective for menstrual migraine.
Common side effects of triptans may include:
Serious side effects may include:
Drugs containing ergotamine (commonly called ergots) constrict smooth muscles, including those in blood vessels, and are useful for migraine. They were the first anti-migraine drugs available. In general, ergotamine does not work as well as triptans but may still be helpful for some people.
Ergotamine is available by prescription in the following preparations:
Side effects of ergotamine include nausea, dizziness, tingling sensations, muscle cramps, and chest or abdominal pain.
The following are potentially serious problems:
Ergotamine can interact with other medications, such as antifungal drugs and some antibiotics. All ergotamine products approved by the FDA contain a "black box" warning on the prescription label explaining these drug interactions.
Ergotamine should not be used by pregnant women because it can cause miscarriage. People with heart or blood circulation conditions should not use these drugs.
Opioid drugs include morphine, codeine, meperidine (Demerol, generic), hydrocodone (Vicodin, generic), and oxycodone (Oxycontin, generic). Opioids are not approved for migraine treatment and should not be used as first-line therapy. Nevertheless, opioid products are sometimes prescribed to treat severe intractable migraine pain. Opioids are not as effective as other types of migraine drugs, and they can have dangerous side effects.
Side effects for all opioids include drowsiness, impaired judgment, nausea, and constipation. There is a risk for addiction, and these drugs can become ineffective with long-term use for chronic migraines. They may also increase the risk of chronic episodic migraines and heightened sensitivity to pain.
Metoclopramide (Reglan, generic) is used in combination with other drugs to treat the nausea and vomiting that sometimes occur either as a medication side effect or migraine symptom. Metoclopramide and other anti-nausea drugs may help the intestine better absorb migraine medications. The battery-powered sumatriptan skin patch (Zecurity) is approved to treat both migraine nausea and pain.
A transcranial magnetic stimulation (TMS) device has been approved by the FDA for treatment of pain caused by migraine headache with aura. It is a portable device that is placed on the head during a migraine attack. The device generates a magnetic pulse, which delivers electrical current to the brain. The current relieves pain by interrupting the abnormal brain activity associated with migraine attacks.
This device is not yet widely available. It is being tested at select headache centers around the United States. The exact role of this device in migraine treatment is unclear at this time.
The FDA's approved drugs for prevention of migraine are:
Propanolol and timolol are beta-blocker drugs. Divalproex, valproate, valproic acid, and topiramate are anti-seizure drugs. Many other drugs are also being used or investigated for preventing migraines.
Beta-blockers are popular prescribed to reduce high blood pressure. Some beta-blockers are also useful in reducing the frequency and severity of migraine attacks.
Propranolol (Inderal, generic) and timolol (Blocadren) are approved specifically for prevention of migraine. Metoprolol (Lopressor, generic) is also recommended. Atenolol (Tenormin, generic), and nadolol (Corgard, generic) are other options for migraine prevention.
Side effects of beta-blockers may include:
If side effects occur, call your health care provider. Never abruptly stop taking a beta-blocker because this can increase the risk for dangerous heart rhythms, heart attack, or other heart problems. Some research suggests that people with migraines who have had a stroke should avoid beta-blockers.
Anti-seizure drugs, also called anticonvulsant drugs, are commonly used for treating epilepsy and bipolar disorder.
Divalproex sodium (Depakote, Depakote ER, generic), valproic acid (Stavzor, Depakene, generic), and valproate sodium (Depacon, generic) are collectively referred to as valproate products. Topiramate (Topamax, generic) is another anti-seizure drug. Valproate products and topiramate are the only anti-seizure drugs that are approved for migraine prevention.
Anti-seizure medication side effects vary by drug but may include:
Pregnant women should never use valproate products to prevent migraine. When taken during pregnancy, these drugs can cause decreased IQ scores in children or can cause life-threatening malformations of the brain and spinal cord. Topiramate can also increase the risk for birth defects, particularly cleft palate. Women who are of childbearing age and considering pregnancy should discuss with their doctors other types of migraine-preventive medication.
All anti-seizure drugs can increase the risks of suicidal thoughts and behavior (suicidality). The highest risk of suicide can occur as soon as 1 week after beginning drug treatment, and can continue for at least 24 weeks. People who take these drugs should be monitored for signs of depression, changes in behavior, or suicidality.
Amitriptyline (Elavil, generic), a tricyclic antidepressant drug, has been used for many years for migraine prevention. It may work best for people who also have depression or insomnia. Tricyclics can have significant side effects, including disturbances in heart rhythms, and can be fatal when overdosed. Although other tricyclic antidepressants may have fewer side effects than amitriptyline, they do not appear to be as effective for migraine prevention.
Venlafaxine (Effexor, generic) is another antidepressant recommended for migraine prevention. It is a serotonin norepinephrine reuptake inhibitor (SNRI). Serotonin-reuptake inhibitors (SSRIs) such as fluoxetine (Prozac, generic) do not appear to be effective for migraine prevention.
OnabotulinumtoxinA (Botox) is approved for preventing chronic migraine in adults. Botox is given by multiple injections to the head and neck area about every 12 weeks. These injections may help to dull future headache symptoms. Botox appears to work best for chronic migraines. It has not been shown to work for migraines that occur less frequently than 14 days a month, or for other types of headaches (such as tension headaches). The most common side effects are neck pain and headache.
The FDA has approved a neurostimulation device for the prevention of migraine headaches. It is a small, portable, battery-powered device that uses transcutaneous electrical nerve stimulation (TENS) to stimulate the trigeminal nerve.
The device resembles a plastic headband and is placed across the forehead. It is used once a day for 20 minutes. In studies, the device helped reduce migraine frequency and use of medication. It did not completely prevent migraines and did not reduce the intensity of migraines that did occur. The exact role of this device in migraine prevention is unclear at this time.
Other types of medications and treatments are being used or investigated for prevention of migraines.
Frovatriptan is effective for prevention of menstrual migraines. Naratriptan (Amerge, generic) and zolmitriptan (Zomig) may also be helpful.
Certain over-the-counter and prescription nonsteroidal anti-inflammatory drugs (NSAIDs) may be helpful for migraine prevention. They include naproxen (Aleve, generic), ibuprofen (Aleve, Motrin, generic), fenoprofen (Nalpron), and ketoprofen (Nexcede, generic). However, daily use of NSAIDs can cause stomach problems and may also lead to a condition called medication overuse headache.
Commonly used for treating high blood pressure, angiotensin converting enzyme (ACE) inhibitors such as lisinopril (Prinivil, generic) block the production of the protein angiotensin, which constricts blood vessels and may be involved in migraine.
Angiotensin-receptor blockers (ARBs) such as candesartan (Atacand) are another type of high blood pressure medication being studied for migraine prevention.
Subcutaneous (under the skin) injections of histamine may be helpful for migraine prevention.
New types of nasal sprays and powders are being researched. Some of them use capsaicin, the chemical found in cayenne peppers, to help relieve pain.
Certain herbs and dietary supplements may be helpful for migraine prevention. See Lifestyle Changes section of this report.
There are several ways to prevent migraine attacks. You should first try a healthy diet, the right amount of sleep, and non-drug approaches (such as biofeedback) for prevention.
Behavioral techniques that reduce stress may help some people with migraines. They include:
Studies generally find that these techniques work best when used in combination with medications.
Many studies have demonstrated that biofeedback is effective for reducing migraine headache frequency. Biofeedback uses special feedback instruments that teach you how to monitor and modify physical responses such as muscle tension.
Relaxation therapy techniques include relaxation response, progressive muscle relaxation, visualization, and deep breathing. Muscle relaxation techniques are simple and easy to learn, and they can be effective.
Some people find that relaxation techniques combined with applying a cold compress to the forehead provide some pain relief during attacks. Some commercially available products use a pad containing a gel that cools the skin for several hours.
Cognitive-behavioral therapy (CBT) teaches how to recognize and cope with life stressors. It can help people understand how their thoughts and behavior patterns may affect their symptoms, and how to change the way the body responds to anticipated pain. CBT may be used in combination with stress management, relaxation, or biofeedback techniques.
Acupuncture is a Chinese medicine that uses thin needles to stimulate specific points aligned with energy pathways in the body. Studies have showed mixed results on the benefits of acupuncture for preventing migraine.
Making a few minor changes in your lifestyle can make your migraines more bearable. Improving sleep habits is important for everyone, and especially those with headaches. What you eat also has a huge impact on migraines, so dietary changes can be extremely beneficial, too.
Avoiding foods and food additives that trigger migraine is an important preventive measure. Common food triggers include monosodium glutamate (MSG), processed lunch meats that contain nitrates, dried fruits that contain sulfites, aged cheese, alcohol and red wine, chocolate, and caffeine. However, people's responses to triggers differ. Keeping a headache diary that tracks diet and headache onset can help identify individual food triggers.
Skipping meals can trigger migraines. It is important to eat on a regular schedule.
Exercise is helpful for relieving stress. An analysis of several studies reported that aerobic exercise in particular might help prevent migraines. It is important to warm up gradually, since sudden, vigorous exercise may trigger or aggravate a migraine attack.
Medications that contain estrogen, such as oral contraceptives and hormone therapy, may trigger migraines or make them worse. Talk to your health care provider about whether you should stop taking these types of medications, reduce the dosage, or switch to another type of drug.
Manufacturers of herbal remedies and dietary supplements do not need Food and Drug Administration approval to sell their products. Just like a drug, herbs and supplements can affect the body's chemistry, and therefore have the potential to produce side effects that may be harmful. There have been several reported cases of serious and even lethal side effects from herbal products. Always check with your provider before using any herbal remedies or dietary supplements.
In 2012, the American Academy of Neurology (AAN) updated its guidelines on migraine prevention to include complementary treatments. Based on reviews of clinical studies, the AAN recommends:
Although not specifically recommended by the AAN, other herbal and dietary supplements associated with migraine prevention include:
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Reviewed By: Amit M. Shelat, DO, FACP, Attending Neurologist and Assistant Professor of Clinical Neurology, SUNY Stony Brook, School of Medicine, Stony Brook, NY. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.